After initially one could only speculate that it would be a Star Trek novel , a little digging suggested that it would be a DS9 novel dealing with the Robinson.
After a blog post by David R. George III on his website confirmed that he has a Star Trek Novel slated for late December without naming a title or series, another blog post now revealed some further information:
In an interesting blog post about the editing process of a Star Trek novel (you should really take the time to read the whole piece, as I don't think we had the process broken down in such detail yet), he confirms that his late December novel is indeed the "mysterious" Original Sin, and through posting a picture of the in-book title page he also (unintentionally?) confirms that it will be DS9.
A few days ago, I received an e-mail from Ed Schlesinger, my administrative editor at Pocket Books, a Simon & Schuster imprint. He informed me that CBS Consumer Products had sent along their notes on my latest manuscript, a Star Trek novel called Original Sin.